Cannabidiol (CBD) has recently become an immensely popular part of the Cannabis industry. CBD is becoming widely accepted in mainstream culture due to its therapeutic properties and recent changes to federal law. l. Many people are beginning to understand how this phytochemical can fit into their daily lives.
With the widespread use of CBD, it is important to be informed about the safety, efficacy, and potential side effects. While rigorous clinical studies are still needed to evaluate the full potential of CBD, preclinical research (including both cell culture and animal models) has shown CBD to have a range of effects that may be therapeutically useful. Potential benefits include anti-seizure, antioxidant, neuroprotective, anti-inflammatory, analgesic, anti-tumor, anti-psychotic, and anti-anxiety properties.
A summary of studies indicate that CBD likely has minimal side effects and is safe for human consumption:
- Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients: According to a study(1) done by Pharmacology in January of 1980, wherein eight healthy volunteers and fifteen epileptic volunteers were observed when taking CBD for a month-long period, the side effects of repeated CBD use seem to be nearly nonexistent. The study found that ‘All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.’
- Open-label evaluation of cannabidiol in dystonic movement disorders: In a study(2) published in 1986 by the International Journal of Neuroscience, five patients with dystonic movement disorders (involuntary muscle contractions that cause repetitive or twisting movements) were given a range of 100mg to600mg of CBD per day. These test subjects showed mild side effects in addition to the benefits they received from Cannabidiol, such as hypotension, dryness of mouth, psychomotor slowing, lightheadedness, and sedation. It was even shown that in high dosages (>300mg) patients actually noticed their Parkinson’s symptoms being slightly agitated, despite CBD being shown to relieve these symptoms overall.
- Inhibition of salivary secretion by activation of cannabinoid receptors: Another notable study(3) that revolved primarily around the side effect of “cotton mouth” or dryness of mouth was observed in a 2006 Argentinian study, which revealed the presence of cannabinoid receptors in human salivary glands. When CBD binds to these receptors, it prevents the production and secretion of saliva to an extent which will leave certain users with a dry mouth.
- Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent: In 2011, one of the most important elements of CBD bodily interactions was uncovered in a review(4) performed by The University of Sao Paulo, SP, Brazil. The review uncovered the fact that CBD, much like certain other natural foods such as grapefruit, may interfere with the hepatic drug metabolism, or reduce the activity of p-glycoprotein. This means that if you are taking any medication where a doctor tells you to not eat grapefruit while on it, you should also not consume CBD as it will have a similar effect. This effect is also why CBD counteracts its partner in crime, THC.
A review of 25 studies on the safety and efficacy of CBD did not identify significant side effects across a variety of dosages. CBD is also present in nabiximols (Sativex) which is approved for use in Europe and other countries. Because of this, there is extensive information available with regard to CBD’s metabolism, toxicology, and safety. However, additional safety testing among specific patient populations may be warranted should an application be made to the Food and Drug Administration.
The best way to determine if you will experience any benefits or side effects from CBD is to consult your physician. When you’ve done the research and come to the conclusion that CBD is the right fit for what ails you, you simply will not find a source as pure, as effective, or as elevated, as the Upstate Elevator Supply Co. Learn more and find your preferred CBD provisions at upstateelevator.com If you have experienced any side effects of CBD (positive or negative) that we have not listed here, please let us know in the comments below!
1. Cunha, J. M., Carlini, E., Pereira, A. E., Ramos, O. L., Pimentel, C., Gagliardi, R., . . . Mechoulam, R. (2008, May 30). Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients. Retrieved December 08, 2017, from https://www.karger.com/Article/Abstract/137430
2. Open label evaluation of cannabidiol in dystonic movement disorders. (n.d.). Retrieved December 08, 2017, from http://www.tandfonline.com/doi/abs/10.3109/00207458608985678
3. Prestifilippo, J. P., Fernández-Solari, J., De, C., Iribarne, M., Suburo, A. M., Rettori, V., . . . Elverdin, J. C. (2006, September). Inhibition of salivary secretion by activation of cannabinoid receptors. Retrieved December 08, 2017, from https://www.ncbi.nlm.nih.gov/pubmed/16946411
4. Bergamaschi, M.M., Costa Quieroz, R.H., Crippa, J.A.S, Zuardi, A.W. (2011, October) Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent. Retrieved December 08, 2017, from http://www.medicinalgenomics.com/wp-content/