As the therapeutic properties of CBD become better known and more people are integrating it into their daily lives, it’s natural to have questions about its safety, efficacy, and potential side effects. While rigorous clinical studies are still needed to evaluate the full potential of CBD, preclinical research (including both cell culture and animal models) has shown CBD to have a range of effects that may be therapeutically useful. Potential benefits may include anti-seizure, antioxidant, neuroprotective, anti-inflammatory, analgesic, anti-tumor, anti-psychotic, and anti-anxiety properties.
For this post, we took a look at a number of studies that have assessed the safety of this phytochemical. Spoiler alert: the research indicates that CBD has minimal side effects and is safe for human consumption. Here’s an overview of what we found.
Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients
According to a study done by Pharmacology in January of 1980, eight healthy volunteers and fifteen epileptic volunteers were observed when taking CBD for a month-long period. The study found that “all patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.”
The study found that “all patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.”
Open-label Evaluation of Cannabidiol in Dystonic Movement Disorders
In a study published in 1986 by the International Journal of Neuroscience, five patients with dystonic movement disorders (involuntary muscle contractions that cause repetitive or twisting movements) were given a range of 100mg to 600mg of CBD per day. In addition to the benefits they received from cannabidiol, these test subjects showed mild side effects such as hypotension, dryness of mouth, psychomotor slowing, lightheadedness, and sedation.
Inhibition of Salivary Secretion by Activation of Cannabinoid Receptors
Another notable study explored the commonly reported side effect of “cotton mouth”, or dryness of mouth, that some people report after using cannabinoids. This 2006 Argentinian study revealed the presence of cannabinoid receptors in human salivary glands. It found that when CBD binds to these receptors, the production and secretion of saliva is inhibited, which may leave some users with a dry mouth. Pesky? Sure. Dangerous? Nope. Just be sure to keep some water handy.
Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
In 2011, one of the most important elements of CBD bodily interactions was uncovered in a review performed by The University of Sao Paulo, SP, Brazil. The review uncovered the fact that CBD, much like certain other natural foods such as grapefruit, may interfere with the hepatic drug metabolism, or reduce the activity of p-glycoprotein. This means that if you are taking any medication where a doctor tells you to not eat grapefruit while on it, you should also not consume CBD, as it will have a similar effect.
A review of 25 studies on the safety and efficacy of CBD did not identify significant side effects across a variety of dosages. CBD is also present in nabiximols (Sativex) which is approved for use in Europe and other countries. Because of this, there is extensive information available with regard to CBD’s metabolism, toxicology, and safety. However, additional safety testing among specific patient populations may be warranted should an application be made to the Food and Drug Administration.
The best way to determine if you will experience any benefits or side effects from CBD is to consult your physician. When you’ve done the research and come to the conclusion that CBD is for you, we encourage you to check out the clean cannabinoid products made by Upstate Elevator Supply Co. Boasting thousands of five star reviews from happy customers, our products are cleanly produced and third party tested, so you know what you’re getting, where it comes from, and how it works.