The Entourage Effect Explained: Why Cannabinoids Work Better Together


Hands pulling Upstate Elevator Strawberry Tangerine and Green Mango seltzer cans from a cooler on the grass

What Is the Entourage Effect?

If you’ve ever wondered why some hemp products seem to work better than others, you might be experiencing the power of the Entourage Effect. This fascinating phenomenon describes how cannabinoids—like CBD, THC, CBG, CBN, and CBDA—work together with terpenes and other plant compounds to create a more profound effect than any single compound alone. At Upstate Elevator, we believe in harnessing this synergy to craft products that deliver real, noticeable results.

The Science: How Cannabinoids and Terpenes Interact

The hemp plant is a botanical powerhouse, containing over a hundred different cannabinoids and a rich array of aromatic terpenes. 

Close-up of a flowering hemp plant with a frosty bud surrounded by serrated green leaves

Each cannabinoid has its own unique properties. For example:

  • CBD (Cannabidiol) is known for its calming and balancing effects.
  • CBG (Cannabigerol) is often called the “mother of all cannabinoids” and supports mood and focus*.
  • CBN (Cannabinol) is prized for its relaxing, snooze-supporting* qualities.
  • THC provides euphoria and deep relaxation.
  • THCV (Tetrahydrocannabivarin) can produce a stimulating, clear-headed high without the munchies.
  • CBDA (Cannabigerolic Acid) is more bioavailable than CBD and may support gut health.

When these cannabinoids are paired together—especially alongside terpenes and flavonoids—their effects can be more pronounced, balanced, and tailored to your needs.

Why Full Spectrum and Multi-Cannabinoid Products Matter

Single-cannabinoid (CBD isolate) products can be effective, but they miss out on the natural synergy found in the whole plant. Full spectrum and multi-cannabinoid blends are designed to maximize the Entourage Effect. By combining cannabinoids and terpenes, these products offer a broader range of benefits—whether you’re seeking calm, focus*, relief, or a better and more sound sleep*.

How to Choose the Right Product for You

Smiling woman holding a strawberry over one eye and a Strawberry Tangerine seltzer can in her other hand

When selecting a multi-cannabinoid product, consider your goals:

If you’re new to cannabinoids, start with a low dose and gradually increase as you learn how your body responds.

Upstate Elevator’s Entourage Effect All-Stars

Ready to experience the Entourage Effect for yourself? Here are some of our favorite products that pair cannabinoids for enhanced benefits:

10mg THC + 5mg CBG Strawberry Tangerine Seltzer

$49.99

Get blessed with zest! Upstate’s Strawberry Tangerine THC+CBG Seltzer is a lightly fruity pick me up for any time, layering sweetly tart tangerine over juicy wild strawberry flavors. Don’t bother counting calories – or artificial flavors or sweeteners – there… read more

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10mg THC + 5mg CBG Strawberry Tangerine Seltzer

A refreshing, fast-acting seltzer that combines 10mg of hemp-derived THC with 5mg of CBG. The result? A balanced, uplifting buzz with mood-boosting and energizing effects—perfect for social occasions or creative afternoons.

Maximum Comfort Capsule, 100mg

$99.99

Maximum Comfort Capsule delivers our most comprehensive hemp profile in a simple daily gelcap. We combine CBDA with our classic cold-extracted, fully activated CBD oil in a measured 1:2 ratio, pairing the acidic and decarboxylated forms of the cannabinoid for… read more

Maximum Comfort Capsule, 100mg

These capsules blend raw CBDA with fully activated CBD oil, offering a comprehensive hemp supplement. CBDA’s bioavailability and digestive support, paired with CBD’s calming properties, make this a powerhouse for daily wellness.

Sleep Raspberry Gummy, 10mg

$19.99

Upstate’s Raspberry gummy pucks are nighttime chill supreme in squishy, fruity form. Each puck is filled with 10mg of pure, hemp-derived THC for a deep body high and topped off with 5mg each of CBD and CBN for relief and… read more

Sleep Raspberry Gummy, 10mg

Nighttime chill in a squishy, fruity form! Each gummy puck delivers a deep body high from THC, plus CBD and CBN for extra relief and relaxation. Pre-scored for easy microdosing.

Uplift THC Strawberry Lemonade Gummies

$19.99

Tap into summer any time of year with Upstate’s Strawberry Lemonade gummy pucks. Each puck is bursting with 10mg of clean, hemp-derived THC paired with 5mg each of mood-boosting CBG and energizing THCV. And each one of those pucks breaks… read more

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Uplift THC Strawberry Lemonade Gummies

A unique trio of cannabinoids—THC, CBG, and THCV—work together for a bright, energizing effect with a delicious strawberry lemonade flavor.

CBD+CBG Yuzu Lemonade Spritz

$24.99

Hold court in the conference room or the living room with our adaptogen-rich CBD + CBG Yuzu Lemonade Spritz. This pro-social blend of CBD, CBG, Magnesium, GABA, and L-Theanine helps level your vibe, while bright, tart yuzu flavor with a… read more

CBD+CBG Yuzu Lemonade Spritz

This sparkling beverage combines calming CBD with focus-friendly CBG* and a burst of citrusy yuzu, making it a perfect pick-me-up for any time of day.

Experience the Entourage Effect with Upstate Elevator

At Upstate Elevator, we’re passionate about clean-crafted, organic hemp products that deliver real results. By embracing the entourage effect, our multi-cannabinoid blends offer a more complete, natural approach to wellness—day or night.

Ready to elevate your routine? Explore our full range of multi-cannabinoid products and discover the difference the entourage effect can make.

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